This approach is to treat the cause of the problem by trying to decrease the production of the certain antibodies. One way this is done is by using drugs which suppress the immune system. All immunosuppressive drugs have side effects. Because these drugs suppress the body’s immune system patients are at increased risk for developing infections. These immunosuppresants also called cytoxic drugs include:

Methotrexate®   (Rheumatrex) is a medicine that is used to treat rheumatoid arthritis (RA) psoriatic arthritis, Reiter's syndrome, and other conditions. First developed to treat certain types of cancer, methotrexate is routinely used at higher doses as a cancer therapy and is now used at much lower doses to treat rheumatic diseases.

Imuran® (Azathioprine) takes approximately 6-12 months to take effect, and it is used for long term control of TA rather than acute treatment. Patients on Imuran may develop low white blood cell counts or platelet counts (another component of blood) and these levels need to be checked regularly. A few people develop nausea and vomiting during the first few months of treatment with Imuran. Although liver abnormalities do occur, they are rare. Still, liver enzymes should be checked periodically while taking Imuran.

Cytoxan® (Cyclophosphamide)Considered for the most severe cases of TA when other therapies have failed.

Please see CYTOXIC DRUG link.

PLEASE NOTE: This information does not cover all generic and brand names, possible uses, actions, precautions, side effects, or interactions of cytotoxic drugs. It should not replace the advice and guidance given to you by your doctor. If you have questions about these or any other medications, please contact your doctor or pharmacist.